Diclofenac sodium enteric-coated tablets caused fewer digestive (nausea, vomiting, abdominal discomfort) and central nervous system-associated (headache, dizziness) side effects than aspirin or indomethacin [20, 103, 104] and were associated with fewer endoscopically confirmed hemorrhagic and erosive lesions in the GI mucosa than naproxen [104 Diclofenac has an average rating of 7.4 out of 10 from a total of 687 ratings on Drugs.com. 69% of reviewers reported a positive effect, while 20% reported a negative effect. Oxycodone has an average rating of 6.9 out of 10 from a total of 1145 ratings on Drugs.com. 63% of reviewers reported a positive effect, while 25% reported a negative effect. Diclofenac. Celebrex is a COX-2-specific NSAID that has a lower propensity for gastrointestinal side effects than many other NSAIDs; however, it still may increase the risk of serious cardiovascular thrombotic more. Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and They may contain ingredients similar to diclofenac (such as aspirin, ibuprofen, ketoprofen, or naproxen). Avoid drinking alcohol. It may increase your risk of stomach bleeding. Avoid exposing treated skin to heat, sunlight, or tanning beds. Heat can increase the amount of diclofenac you absorb through your skin. Several topical products (Voltaren Arthritis Pain, Pennsaid, others) are made with a nonsteroidal anti-inflammatory medicine called diclofenac. They treat osteoarthritis in joints that are close to the skin, such as the hands and knees. These products were once available only by prescription. But now you can get them without a prescription. Diclofenac is an effective medicine for relieving pain but may be associated with an increased risk of cardiovascular and gastrointestinal side effects compared with some other NSAIDs. Prescribed more. Prescription only. Gabapentin may be used in the treatment of partial-onset seizures and nerve pain but is likely to cause dizziness or Diclofenac is mostly sold with prescription and is more potent than ibuprofen. It mostly comes in 25, 50, and 75 mg tablets. The only form of diclofenac that can be purchased without prescription is the topical gel. The recommended daily dosage of the drug is between 50 – 150 mg. Ibuprofen can be gotten as an over-the-counter medication (OTC). Naproxen (Aleve) and ibuprofen (Advil) are available at higher strengths as prescriptions and lower strengths when purchased over the counter. In this article, we provide an overview of the Although the efficacy of celecoxib compared with diclofenac and naproxen in relieving pain and improving physical function in patients with OA has previously been established, 16 –21 to date there has been little direct evidence comparing celecoxib with ibuprofen, despite ibuprofen being one of the most commonly used NSAIDs. • Diclofenac has more selectivity for COX-2 than naproxen. • Diclofenac appears to inhibit the lipoxygenase pathways, reducing inflammation by decreasing production of leukotrienes. • Diclofenac also inhibits arachidonic acid release and stimulates its reuptake IEdpi9q.